Skip to main content
. 2020 Dec 22;1(9):100155. doi: 10.1016/j.xcrm.2020.100155

Figure 5.

Figure 5

Properties of the DENV-Reactive Serum Antibody Response in Flavivirus-Naive Subjects That Received the Live Attenuated Tetravalent DENV Vaccine TV003

The properties of the serum DENV-binding response in convalescent (6 months after vaccination) TV003 vaccinees was determined by virus depletion and DENV-binding ELISAs.

(A) Type-specific and cross-reactive binding to each serotype was determined. Boxplots represent the 25th–75th percentiles with whiskers showing the 5th–95th percentiles, with the horizontal bar showing the median of the fraction of each type of antibody measured across subjects (n = 21 subjects).

(B) The proportions of DENV2-reactive serum antibodies were classified as type specific (open bars) and cross-reactive (hatched bars) was determined for a subset of 9 subjects with memory B cell reactivity data (see Figure 4). At least 2 technical replicates were performed for all ELISA-binding measurements.