Figure 3.

In Vivo Barcode Virus Infection and Effects of LRA on Rebound

(A) Schematic representation of infection procedure intended to overcome potential transmission bottlenecks and increase barcode diversity during initial infection of humanized mice.

(B) Viral loads of mice at each phase of infection. Primary infections lasted 4–5 weeks, followed by 6–7 weeks of antiretroviral therapy (ART). SUW133 (LRA) (n = 15 mice) or control injections (n = 11 mice) were administered 4 days before stopping ART, to allow latently infected cells sufficient time to die after reactivation. See Figure S3 for individual viral load plots for each animal.

(C) Delay in viral rebound induced by SUW133 versus DMSO control-treated animals compared using a log-rank (Mantel-Cox) test.

See also Table S1 and Figures S2–S5.