Figure 5.

Tumor Organoids Capture Inter-patient Heterogeneous Responses to Anticancer Drugs

(A) Heatmap of cell viability profiled for organoids derived from 21 patients of different tumors conditioned in 31 individual anticancer compounds. The organoids were cultured under the drug-free conditions for 7 days before being dosed with single drugs at 10 μM for 2 days (n = 5).

(B) Heatmap of the organoid response and patients’ clinical outcomes.

(C–H) Drug efficacy profiles (C–E) (n = 5) and computed tomography (CT) (F–H) of patient tumors matching (C, F, and D, G) or mismatching (E, H) the screening outcomes before and after the anticancer treatment for colon (F), rectal (G), and liver (H) tumors.

See also Figures S4–S6 and Tables S1 and S2.