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. 2020 Dec 22;1(9):100161. doi: 10.1016/j.xcrm.2020.100161

Figure 6.

Figure 6

Dose Responses to Chemotherapy in Rectal Tumor Organoids

(A–D) Chemosensitivity of P37, P38 organoids to 5-FU (A), leucovorin (B), Oxaliplatin (C), FOLFOX (D) (5-Fu: leucovorin: Oxaliplatin = 25:5:1) in the form of dose-response curves (n = 3). AUC was calculated from the raw dose-response data.

(E–H) Dose responses to chemotherapy in droplet organoids and traditional organoids. Chemosensitivity of P33 organoids to 5-FU (E), leucovorin (F), Oxaliplatin (G), and FOLFOX (H) (5-Fu: Leucovorin: Oxaliplatin = 25:5:1) in the form of dose-response curves (n = 3). AUC was calculated from the raw dose response data.

(I and J) The heatmaps show the values of IC50 of P37 and P38 organoids (I), and responses of P33 droplet organoids (DO) and traditional organoids (TO) to 5-FU (5F), leucovorin (LE), Oxaliplatin (OX), FOLFOX (FO) (J). The colors code sensitivity (blue) and resistance (orange) at an arbitrary cutoff value of 10 μM. See also Table S2.