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S‐metoprolol succinate apparent oral clearance by CYP2D6 activity score. Pharmacokinetic data are shown for the natural log of S‐metoprolol apparent oral clearance (ln(CLo)) by CYP2D6 AS. After adjusting for other clinical predictors (sex, race, age, and body mass index) CYP2D6 AS was significantly associated with S‐metoprolol ln(CLo) (adjusted P < 0.001).
