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. 2020 Nov 3;9(12):678–685. doi: 10.1002/psp4.12563

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© 2020 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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S‐metoprolol succinate apparent oral clearance by CYP2D6 activity score after considering the functional effects of rs5758550. Pharmacokinetic data are shown for the natural log of S‐metoprolol apparent oral clearance (ln(CLo)) by CYP2D6 AS after accounting for rs5758550, a CYP2D6 enhancer single nucleotide polymorphism. After adjusting for other clinical predictors (sex, race, age, and body mass index) CYP2D6 AS was significantly associated with metoprolol ln(CLo) (adjusted P < 0.001).