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Change in heart rate with metoprolol tartrate by CYP2D6 activity score (AS) after considering the functional effects of rs5758550. Pharmacodynamic data are shown for change in heart rate (HR) after 2 weeks of metoprolol tartrate by CYP2D6 AS after accounting for rs5758550, a CYP2D6 enhancer single nucleotide polymorphism. After adjusting for other clinical predictors (sex, race, age, and body mass index) CYP2D6 AS was significantly associated with change in HR (adjusted P < 0.001).
