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. 2021 Jan;97:148.e17–148.e24. doi: 10.1016/j.neurobiolaging.2020.07.002

Fig. 2.

Fig. 2

Forest plot of meta-analyses for DNM3 rs2421947 and VAMP4 rs11578699. (A, C, and E) Cox proportional hazards model meta-analyses of LRRK2 p.G2019S carriers; (B, D, and F) linear regression meta-analyses of LRRK2 p.G2019S patients. (A, B) Meta-analyses of DNM3 rs2421947 GG versus CG and CC genotypes of novel data from this manuscript from 724 LRRK2 p.G2019S carriers; (C, D) Meta-analyses of DNM3 rs2421947 GG versus CG and CC genotypes from 1478 LRRK2 p.G2019S carriers including 754 previously published; (E, F) VAMP4 rs11578699 meta-analyses of CC versus TT and TC. Percentage contribution and numbers of individuals included in each analysis are indicated. Analyses are carried out on ethnicity subgroups: Ashkenazi Jewish (Summary: AJ), European (Summary: EU), and North African (Summary: NA). Abbreviations: DNM3, Dynamin 3; LRRK2, leucine-rich repeat kinase 2; VAMP4, vesicle-associated membrane protein 4.