Table 5.
Antigen | Adjuvant | Immunization Method | Challenge Strain | Challenge Method | Animal Model | Protection | Ref |
---|---|---|---|---|---|---|---|
pcDNA-FliC | CpG ODN | i.m. | B. pseudomallei | i.v. (105 CFU) | BALB/c mice | 93.3% at day 12 | [64] |
pVAX-hTPA-FliC | Polyethylenimine | i.n. | B. pseudomallei | i.n. (500 CFU) | C57BL/6 | 53% at day 14 | [103] |
a Abbreviations: i.m., intramuscular; i.n., intranasal; i.v., intravenous; CFU, colony forming units.