Figure 1.

(A–C) Histological observation of perineural satellitosis in glioblastoma. Haematoxylin and eosin stain show (A) Anaplastic, frankly malignant glial tumour cells (tc) induced neuronal apoptosis (B): only the picnotic remnant (Nr) of the neuron remains. In the end, (C) the vanishing neuron will be completely replaced by tumour cells (ø). What normally occurs is that neoplastic cells surround the neuronal cell body, which then results in neuronal cell death with intracellular degenerative change and appearance of ‘ghost cells’ surrounded by the neoplastic cells in electron microscopy studies. The neoplastic cells can also phagocytose the remains of the neurons. For detailed information refer to [11,12]. Original images are collected at 400× magnification and relative region of interest (ROI) is reported. The scale bars are 20 µm.