Figure 4.

Histological observation and description of (A) perineuronal satellitosis in glioblastomas (GB) and (B) perineuronal satellitosis in non-neoplastic brain damage condition. (A). Polymorphic, markedly atypical glial tumour cells (tc) surrounding a neuron (Nr), which nevertheless shows only mild sign of cellular, mostly hypoxic stress (darkened colour of nucleus and cytoplasm, focal vacuolisation, chromatic dispersion); (B) Slightly atypical, non-neoplastic glial cells (g) are surrounding neurons (Nr) with little changes, mostly due to hypoxic stress, in the collateral brain tissue of an active plaque (patient with relapsing multiple sclerosis). The contact between the cell’s shapes, not only cytoplasmic but also nucleus structure, creating nuclear membrane indentations (►). All images are shown at 400× magnification and relative regions of interest (ROI) are reported. The scale bars are 50 µm.