Table.

Table. Cytotoxic activity (IC50, µM) of the final compounds (1–16) against various cancer cell lines and their selectivity index values.

Com	R	A	SH-SY5Y	PANC-1	MDA-MB-231	MCF-10a	SI*
1	hydrogen	phenyl	92.2 ± 1.5	86.7 ± 1.4	140.4 ± 1.1	78.2 ± 1.6	0
2	chloro	phenyl	29.0 ± 1.5	86.6 ± 1.6	99.7 ± 1.1	232.9 ± 2.1	2.3
3	methoxy	phenyl	57.4 ± 1.6	103.7 ± 1.6	110.6 ± 1.2	98.9 ± 1.2	0
4	methyl	phenyl	75.9 ± 1.6	86.6 ± 1.4	89.7 ± 1.5	132.2 ± 1.7	1.5
5	hydrogen	morpholine	118.4 ± 1.8	24.2 ± 2.1	102.9 ± 1.7	89.6 ± 1.5	0
6	chloro	morpholine	80.6 ± 1.9	8.8 ± 2.1	136.5 ± 1.5	70.7 ± 1.8	0
7	methoxy	morpholine	134.0 ± 1.7	1.2 ± 1.8	77.01 ± 1.7	118.5 ± 1.2	1.5
8	methyl	morpholine	79.3 ± 1.6	120.3 ± 1.2	81.5 ± 1.2	81.4 ± 1.3	1
9	hydrogen	hydrogen	81.1 ± 2.1	85.5 ± 1.7	99.8 ± 1.7	108.8 ± 1.1	1.1
10	chloro	hydrogen	38.6 ± 1.6	89.1 ± 1.7	79.1 ± 1.3	172.1 ± 1.4	2.2
11	methoxy	hydrogen	237.8 ± 1.7	83.8 ± 1.5	114.3 ± 1.3	81.1 ± 1.4	0
12	methyl	hydrogen	79.5 ± 1.8	44.6 ± 1.9	81.0 ± 1.6	106.3 ± 1.4	1.3
13	hydrogen	4-methoxyphenyl	47.5 ± 1.5	17.9 ± 2.1	76.1 ± 1.6	217.8 ± 1.3	2.9
14	chloro	4-methoxyphenyl	26.0 ± 1.4	22.5 ± 1.7	19.9 ± 1.7	109.2 ± 1.2	5.5
15	methoxy	4-methoxyphenyl	39.9 ± 1.6	18.1 ± 1.6	33.9 ± 1.8	118.4 ± 1.4	3.5
16	methyl	4-methoxyphenyl	32.7 ± 1.7	21.4 ± 1.7	15.7 ± 1.9	132.9 ± 1.2	8.5
Cisp			NT	0.017	0.017	0.017

*Selectivity index represents the ratio between the IC50 value calculated for the cancerous breast cell line (MDA-MB-231) and the IC50 value calculated for the normal breast cell line (MCF-10a). SH-SY5Y–human neuroblastoma; MDA-MB-231–triple-negative breast cancer; PANC‑1–human pancreatic cancer; and MCF-10a–human mammary cell lines.