Table.

The inhibitory effects of the compounds 3a–g onCAs isoenzymes.

Compounds	IC50						Ki (nM)
	hCA I(nM)	r2	hCA II(nM)	r2	AChE(nM)	r2	hCA I	hCA II	AChE
2	40.76	0.9828	46.20	0.9773	38.50	0.9921	50.34 ± 1.59	62.54 ± 11.51	21.19 ± 2.35
3a	27.72	0.9786	20.38	0.9850	16.90	0.9748	17.62 ± 4.72	18.67 ± 1.59	10.60 ± 2.07
3b	19.80	0.9784	24.75	0.9917	12.38	0.9805	29.70 ± 3.18	12.62 ± 2.54	13.29 ± 1.08
3c	20.38	0.9773	30.13	0.9987	21.66	0.9789	6.33 ± 0.51	10.68 ± 0.98	18.50 ± 3.87
3d	22.35	0.9775	21.00	0.9837	21.00	0.9805	9.16 ± 0.46	16.86 ± 3.76	13.29 ± 1.63
3e	25.67	0.9922	25.67	0.9829	26.65	0.9723	8.02 ± 0.88	37.16 ± 7.55	34.02 ± 5.90
3f	28.88	0.9827	24.75	0.9902	9.11	0.9904	11.35 ± 1.70	21.35 ± 3.47	8.91 ± 1.65
3g	21.00	0.9869	26.65	0.9912	12.16	0.9824	4.07 ± 0.38	14.88 ± 3.10	13.19 ± 5.15
AZA	46.75	0.9932	38.25	0.9890	-	-	30.74 ± 3.52	22.27 ± 1.56	-
TAC	-	-	-	-	25.78	0.9878	-	-	18.45 ± 2.12