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. 2020 Dec 9;12(12):1417. doi: 10.3390/v12121417

Figure 1.

Figure 1

Schematic representation of HLA region located on the short arm of chromosome 6 (6p21.1 to p21.3). The HLA gene complex is subdivided into class I, class II and class III regions based on the structure and function of the molecules that these genes encode. The HLA class I and class II genes encode molecules that bind and present peptide fragments while the class III region contains genes for cytokines and the components of the complement system. HLA genes are codominant expressed and highly polymorphic with 25,958 allele sequencies known to date (IPD-IMGT/HLA Database on 1 October 2020). Only the number of HLA class I alleles and proteins are shown since they are ligands for KIRs.