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Effect of TLR7/8 on DAT expression in SN of MPTP-treated mice. Immunohistochemical analysis of midbrain obtained from WT mice after MPTP intoxication revealed an important loss of DAT-positive cells (b; see densitometric analysis d) compared to WT (a, see densitometric analysis d); while the absence of TLR7/8 preserved the reductions of DAT (c; see densitometric analysis d). Data are means ± SEM of 10 mice for each group. *** p < 0.001 vs. SHAM WT; ### p < 0.001 vs. MPTP WT.
