Table 1.

Role of miRNAs in cancer progression.

miRNA		Cancer Type	Target	Role in Vitro	Role in Vivo	Ref.
OncomiRs	miR-9	Breast cancer	CDH1	↑ cell migration and invasiveness	↑ tumor invasion and metastasis ↑ angiogenesis	[24]
	miR-10b	Breast cancer	HOXD10	↑ cell migration and invasiveness	↑ tumor invasion and metastasis	[25]
	miR-17-5p	Colorectal cancer	PTEN, P130	↑ cell migration and invasiveness	↑ tumor growth	[26,27]
	miR-19b	Breast cancer	TP53	↑ cell migration and invasiveness, cell cycle progression	↑ tumor growth and metastasis	[28]
	miR-21	Colorectal cancer	Pdcd4	↑ cell invasiveness	↑ intravasation and metastasis	[29]
	miR-135b	Lung cancer	LZTS1, Hippo pathway	↑ cell migration and invasiveness	↑ tumor growth and metastasis	[30]
	miR-181a	Breast cancer	Bim	↑ cell migration and invasiveness ↓ anoikis	↑ tumor growth and metastasis	[31]
	miR-214	Melanoma	TFAP2C, ITGA3	↑ cell migration and invasiveness	↑ extravasation and metastasis	[32]
	miR-211	Colorectal cancer	CHD5	↑ cells proliferation and migration	↑ tumor growth	[33]
	miR-223	Gastric cancer	EPB41L3	↑ cells motility and invasiveness	↑ metastasis	[34]
Tumor suppressor miRs	miR-34a	Neuroblastoma	MAP3K9	↑ induction of cell cycle arrest and apoptosis	↓ tumor growth	[35]
	miR-137	Colorectal cancer	FMNL2	↓ cells proliferation and invasion	↓ metastasis	[36]
	miR-192	Colon cancer	Bcl-2, ZEB2	↑ apoptosis	↓ metastasis	[37]
	miR-375	Liver cancer	AEG-1	↓ cell growth and invasiveness	↓ tumor growth	[38]
	miR-874	Non-small cell lung cancer	MMP-2, uPA	↓ cells invasiveness	↓ tumor growth	[39]
	let-7	Lung cancer	KRAS	↓ cell proliferation	↓ tumor growth	[40]

↑—increase, ↓—decrease.