Table 5.
MiRNAs regulating cancer cell invasiveness and their direct targets.
| miRNAs Promoting Invasiveness | miRNAs Suppressing Invasiveness | ||||
|---|---|---|---|---|---|
| miRNA | Targets | Ref. | miRNA | Targets | Ref. |
| miR-9 | SOX7, CDH1, α-catenin | [24,256,257,258] | miR-10b | IGF-1R, HOXA-3, FGF13 | [259,260,261] |
| miR-10b | TP53, PAX6, NOTCH1, HOXD10, TIP30, KLF4, HOXB3 | [259,262,263,264,265] | miR-29c | CDK6, ITGB1, TIAM1, Collagens, Laminin γ1 | [193,266,267,268] |
| miR-21 | PDCD4, maspin, HBP1, LZTFL1, KLF5 | [185,269,270,271,272] | miR-34a | SATB2, BCL-2, HNF4α, Snail, MMP9, MMP14, Notch1 | [273,274,275,276,277,278] |
| miR-103 | DAPK, KLF4, OLFM4, LATS2, PTEN | [279,280,281,282] | miR-135a | ROCK1, Smo, ERRα | [283,284,285] |
| miR-107 | TPM1, DAPK, KLF4 | [279,286] | miR-145 | PAK4, ROCK1, MMP11, Rab27a, MUC1, MMP16, N-cadherin, ZEB2, Ets1, KLF4 | [88,287,288,289,290,291,292,293] |
| miR-135b | NR3C2, LZTS1, APC, FOXO1, ST6GALNAC2, RECK, EVI5 | [30,71,294,295,296,297] | miR-148b | WNT1, MTA2, ROCK1, Dock6 | [298,299,300,301] |
| miR-155 | DOCK-1, SDCBP, ANXA-2, CLDN-1, NDFIP1, SOCS1, TP53INP1, BCL6 | [302,303,304,305,306] | miR-200 | Foxf2, Flt1, BMP4, Onecut2, LIMK1, BMI-1, E2F3 | [307,308,309,310,311] |
| miR-223 | PAX6, hFBXW7, EPB41L3 | [34,312,313] | miR-214 | JAG1, ROCK1, CDC25B, ARL2, GALNT7, MKK3, JAK1 | [314,315,316,317,318,319,320] |
| miR-424 | CADM1, SMAD7 | [321,322] | miR-340 | NT5E, EphA3, SIRT7, NF-κB1, RhoA, ROCK1, JAK1 | [85,323,324,325,326,327,328] |