Table 2.

Clofazimine drug delivery systems for leprosy therapy.

Type of Delivery System	Composition	Major Outcome	Ref
Oral Administration
Solid lipid nanoparticles	Precirol ATO 5 Tween 80	gastric and intestinal cells tolerate more CLZ when loaded in the nanoparticles than free in solution	[84]
Polymeric nanoparticles	PLGA	nanoparticles decreased drug intrinsic toxicity, with improved intestinal permeation	[85]
Transdermal administration
Liposomes	Phosphatidylcholine Cholesterol HPMC (matrix to deliver liposomes)	liposomal gels were found to be stable at room temperature for up to 3 months	[86]
Other applications
Solid dispersions	Hypromellose phthalate Hypromellose vinylpyrrolidone-vinyl acetate	elucidation of a possible structural model of the drug–polymer complex	[87]
Solid dispersions	Hypromellose phthalate Hypromellose vinylpyrrolidone-vinyl acetate	contribution to a rational selection of appropriate polymeric carriers	[88]