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Synovial fluid-derived EV cargo proteins significantly dysregulated in female samples. (a) Haptoglobin, (b) Ceruloplasmin, (c) Anti-folate binding protein, (d) V1-5 protein, (e) Apolipoprotein L and (f) HRV Fab N27-VL. Differences between normal and OA patients were examined using Student’s t-test (FN = female non-OA (n = 8), FO = female OA (n = 10), MN = male non-OA (n = 7), MO = male OA (n = 7), * p = 0.04, # p = 0.01).
