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Synovial fluid-derived EV cargo proteins significantly dysregulated in male samples (n = 8–10/group). (a) Complement Component variant 5, (b) Collagen alpha-1 (VI) chain, (c) Beta-2-glycoprotein I, (d) SAGA-associated factor 29 and (e) KIAA1466 protein. Differences between normal and OA patients were examined using Student’s t-test (FN = female non-OA (n = 8), FO = female OA (n = 10), MN = male non-OA (n = 7), MO = male OA (n = 7), * p = 0.04, # p = 0.01).
