Table 2.

Selected Database for Annotation, Visualization, and Integrated Discovery (DAVID) Gene Ontology (GO) pathways affected by EVs cargo proteins in female OA.

GO Term	p Value
GO:0006898~receptor-mediated endocytosis	0.00072
GO:0004252~serine-type endopeptidase activity	0.00134
GO:0008236~serine-type peptidase activity	0.00163
GO:0017171~serine hydrolase activity	0.00167
GO:0006898~receptor-mediated endocytosis	0.00232
GO:0005576~extracellular region	0.00257
GO:0004175~endopeptidase activity	0.00495
GO:0006897~endocytosis	0.00891
GO:0070011~peptidase activity, acting on L-amino acid peptides	0.00996
GO:0008233~peptidase activity	0.01066
GO:0002376~immune system process	0.01125
GO:0016787~hydrolase activity	0.01296
GO:0016192~vesicle-mediated transport	0.04203
GO:0006955~immune response	0.04508
GO:0005576~extracellular region	0.05286
GO:0072562~blood microparticle	0.00041
GO:0005576~extracellular region	0.00257
GO:0002376~immune system process	0.01125
GO:0005615~extracellular space	0.02962
GO:0006950~response to stress	0.03508
GO:0006952~defense response	0.04330