Table 3.

Selected QuickGO pathways affected by EVs cargo proteins in female OA.

Biological Function Involved	Signaling Involved
biological_process	lipid transport
biological_process	regulation of immune system process
biological_process	lipoprotein metabolic process
biological_process	receptor-mediated endocytosis
biological_process	Fc-epsilon receptor signaling pathway
biological_process	Fc-gamma receptor signaling pathway involved in phagocytosis
biological_process	complement activation
biological_process	complement activation, classical pathway
biological_process	proteolysis
biological_process	leukocyte migration
biological_process	regulation of immune response
biological_process	DNA recombination
biological_process	regulation of complement activation
molecular_function	hydrolase activity
molecular_function	ATP-dependent helicase activity
molecular_function	nucleic acid binding
molecular_function	serine-type endopeptidase activity
molecular_function	helicase activity
molecular_function	nucleotide binding
molecular_function	lipid binding
molecular_function	ATP binding
molecular_function	hemoglobin binding
cellular_component	extracellular region
cellular_component	nucleus
cellular_component	nucleoplasm
cellular_component	collagen trimer
cellular_component	extracellular space