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The role of TNAP within the purinergic signaling. ATP/ADP/AMP: adenosine tri-/die-/monophosphate, cAMP: cyclic adenosine monophosphate, DAG: diacylglycerol, CD39/ENTPDase1: ectonucleoside triphosphate diphosphohydrolase 1, IP3: Inositol trisphosphate, CD73/NT5E: ecto-5′-nucleotidase, PIP2: phosphatidylinositol 4,5-bisphosphate, PKA: phosphokinase A, PLC: phospholipase C, TNAP: tissue-nonspecific alkaline phosphatase.
