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. 2020 Dec 8;10(12):1648. doi: 10.3390/biom10121648

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TNAP function is linked to PLP/cofactor, neurotrophic factor and myelin synthesis. (A) TNAP’s influence on the GABA synthesis. (B) TNAP’s role in the catecholamine and serotonin synthesis. (C) TNAP’s impact on purinergic signaling. (D) TNAP’s role in the myelin synthesis pathway. HTP: 5-hydroxytryptophan, AADC: aromatic L-amino acid decarboxylase, ATP/ADP/AMP: adenosine tri-/di-/monophosphate, BBB: blood–brain barrier, GABA: gamma-aminobutyric acid, GAD: glutamate decarboxylase, L-DOPA: levodopa, PDXK: pyridoxal kinase, PLP: pyridoxal-5′-phosphate, TNAP: tissue-nonspecific alkaline phosphatase.