Table 3.

IOP lowering effects of inhaled cannabinoids.

Authors	Study Population	Intervention	Results
Hepler et al., 1971 [4]	11 healthy subjects	18 mg delta-9-THC	24% IOP lowering (limited data available)
Flom et al., 1975 [20]	15 healthy subjects	12 mg delta-9-THC	13% IOP lowering after 80 min from administration
Hepler et al., 1976 [56]	136 subjects affected by POAG administered with 1, 2, or 4% THC cigarette	20 mg delta-9-THC (2 g marijuana cigarette with 1% delta-9-THC)	29% and 22% IOP lowering after 30 and 180 min from administration
		40 mg delta-9-THC (2 g marijuana cigarette with 2% delta-9-THC)	25% and 17% IOP lowering after 30 and 180 min from administration
		80 mg delta-9-THC (2 g marijuana cigarette with 4% delta-9-THC)	34% and 22% IOP lowering after 30 and 180 min from administration
Hepler et al., 1976 [57]	40 healthy subjects	1% natural delta-9-THC cigarette	30% IOP lowering 30 min after administration
		2% natural delta-9-THC cigarette	25% IOP lowering 30 min after administration
		4% natural delta-9-THC cigarette	34% IOP lowering min after administration
		1% synthetic delta-9-THC cigarette	15% IOP lowering 30 min after administration
		2% synthetic delta-9-THC cigarette	23% IOP lowering 30 min after administration
		4% synthetic delta-9-THC cigarette	24% IOP lowering 30 min after administration
Merritt et al., 1980 [65]	18 glaucoma patients (12 affected by POAG, 6 affected by secondary glaucoma)	18 mg delta-9-THC (0.9 g marijuana cigarette with 2% delta-9-THC)	14.5% and 23.4% IOP lowering after 30 and 90 min from administration

(POAG: primary open angle glaucoma, IOP intraocular pressure, THC Tetrahydrocannabinol.).