Figure 6. Aortic aneurysm development in Fbn1^C1039G/+ male mice treated with flutamide.

Diameter (mm) and aortic growth (mm) of aortic root (A) and ascending aorta (B) in Fbn1^C1039G/+ (Fbn1) and littermate wild type control mice (WT) males treated with flutamide or vehicle control measured by transthoracic echocardiography at ages 6, 8, 12, and 16 weeks (Fbn1 vehicle n=9, Fbn1 flutamide n=9, WT vehicle, n=8, WT flutamide n=7). Results presented as mean±SD. Mixed effects model used for aortic growth comparison between groups. C, Average number of elastin lamina breaks per lamellae with representative elastin histological staining (EVG) in aortic root from Fbn1 treated with flutamide or vehicle control at 16 weeks (n=5, each group). Scale bars represent 50 μm. Results presented as median±interquartile. Mann–Whitney U test used for comparison between groups. *P≤0.05, **P<0.01, ***P<0.001.