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. 2020 Oct 22;9(21):e017748. doi: 10.1161/JAHA.120.017748

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© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A, Isolated, intact rodent heart with retrograde Langendorff‐perfusion via an aortic cannula. Pacing electrodes were attached to the RA and apex of the LV to perform an EP. B, Experimental timeline included 30‐minutes perfusion with KH media, containing 4.5 mM K⁺ (control), which commenced with an EP protocol. Thereafter, the media remained unchanged (control), supplemented with 10% sRBC, or supplemented with increasing potassium concentrations. The EP study was repeated again after 15–20 minutes, and results were compared with baseline. Timeline created using biorender.com. EP indicates electrophysiology study; KH, Krebs‐Henseleit media; LV, left ventricle; RA, right atria; and sRBC, supernatant from red blood cell units.