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. 2020 Oct 22;9(21):e017748. doi: 10.1161/JAHA.120.017748

Figure 4. RBC storage age is associated with increased refractoriness of the AV node.

Figure 4

A, Biosignals recorded with atrial pacing (S1‐S1) to measure WBCL in isolated hearts in the presence of day 7 sRBC, (B) day 40 sRBC, or (C) 10 mM K+. D, Slowed AV node conduction following exposure to sRBC from older units, but not “fresh” day 7 units. E, Slowed AV conduction following exposure to 10–12 mM K+. Arrowheads denote ventricular response to atrial pacing at S1 (black) pacing cycle length. ≠ denotes failed conduction. Mean±SEM, *P<0.05, n≥3. AV indicates atrioventricular; sRBC, supernatant from red blood cell units; and WBCL, Wenckebach cycle length.