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. 2020 Oct 22;9(21):e017748. doi: 10.1161/JAHA.120.017748

Figure 6. RBC storage age is associated with increased ventricular refractoriness.

Figure 6

A, Biosignals recorded with ventricular pacing (S1–S2) to pinpoint the VERP in isolated hearts perfused with media supplemented with 10% sRBC collected from a day 7 unit, (B) day 40 unit, or (C) 10 mM K+. D, Ventricular refractoriness was unchanged after exposure to day 7–30, but increased with day 40–50 sRBC and (E) media supplemented with 8–12 mM K+. Arrowheads denote ventricular response to pacing at S1 (black) or S2 (gray) pacing cycle length. ≠ denotes failed conduction. Mean±SD, *P<0.05, n=3–6. RBC indicates red blood cell; sRBC, supernatant from red blood cell units; and VERP, ventricular effective refractory period.