Table 1.
Prognostic significance of various prognostic factors relevant to ovarian carcinosarcoma.
| Prognostic Factors | Favourable | Unfavourable |
|---|---|---|
| Patient’s age | <65 years | >65 years |
| Initial tumour stage | Early | Advanced |
| Surgery | Optimal surgical resection | Suboptimal surgical resection |
| Ca-125 levels at presentation | Low | High |
| Epithelial carcinoma histologic grade | Low | High |
| Myometrial vascular invasion | No | Yes |
| Epithelial components | Non-serous | Serous |
| Sarcomatous components | Homologous | Heterologous |
| Sarcomatous components outside the ovary | No | Yes |
| Presence of sarcomatous components | <25% | >25% |
| Histological stromal sarcoma predominance | No | Yes |
| Number of small vessels in the primary tumour | Low | High |
| VEGF, VEGFR-3 expression | Normal | Increased |
| P53 overexpression | Absent | Presented |
| Ki67 reactivity | Low | High |
| Adjuvant chemotherapy | Platinum-based regimens | Non-platinum-based regimes |
Legend: VEGF—Vascular endothelial growth factor; VEGFR-3—Vascular endothelial growth factor receptor 3; P53—protein 53; Ki67—antigen Ki67.