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Oxidation parameters of the hemoglobin Providence constructs.
| Treatment Conditions HPAECs |
Cys93 Oxidation | Cys93 Oxidation | Cys93 Oxidation |
|---|---|---|---|
| 2.5:1 | 5:1 | 10:1 | |
| (H2O2:heme) | (H2O2:heme) | (H2O2:heme) | |
| HbA [18] | 21 ± 4.2% | 31 ± 2.8% | 58 ± 3.8% |
| HbS (βE6V) [18] | 32.9 ± 2.7% | 64 ± 5.0% | 67% ± 6.8 |
| Hb Prov (βK82D) | 6.8 ± 3.1% | 11.6 ± 0.8% | 9.5 ± 4.3% |
| HbS Prov (βE6V/βK82D) [16] | 11.9 ± 2.0% | N/A | 22 ± 1.3% |
| Crosslinked Providence (rHb0.1 Prov) [15] | Below detection | Below detection | 2.7 ± 0.2% |
