Table 5.
Analyses of the entire CHEK2 coding sequence (separately or as a part of panel NGS) or analyses of specific variant(s) in colorectal cancer (CRC) patients.
| Reference | Population | P: Patients C: Controls |
Analysis | Odds Ratio (95% Confidence Interval); p—Remark (Statistically Insignificant in Italics) |
|---|---|---|---|---|
| Xiang 2017 [230] |
meta | Revision of the analysis from [231] | 1.8 (1.2–2.7)—unselected CRC 2.4 (0.9–6.6)—familial CRC 1.7 (0.9–2.9)–sporadic CRC |
|
| Naslund-Koch 2016 [156] | DK | 1131/86,975 individuals developed CRC | c.1100delC | 0.86 (0.43–1.72);0.68 |
| Ma 2014 [232] |
meta | P: 3874 CRC/ C:11,630 P: 6042 CRC/ C:17,051 |
c.1100delC p.I157T |
1.88 (1.29–2.73); 0.001 1.56 (1.32–1.84); 1.22 × 10−7 |
| Han 2013 [172] |
meta | P: 3166 CRC C: 9844 |
p.I157T | 1.67 (1.24–2.26); 0.0008 |
| Liu 2012 [233] |
meta | P: 4029 CRC C: 13,844 |
p.I157T | 1.61 (1.40–1.87); <0.001—unselected CRC 1.48 (1.23–1.77); <0.001—sporadic CRC 1.97 (1.41–2.74); <0.001—familial CRC |
| Xiang 2011 [231] |
meta | P: 4,194 CRC C: 10,010 |
c.1100delC | 2.11 (1.41–3.16); 0.0003—unselected CRC 2.80 (1.74–4.51); <0.0001—familial CRC 1.45 (0.49–4.30); 0.5—sporadic CRC |
| Suchy 2010 [234] |
PL | P: 463 HNPCC-related C: 5496 PMC |
c.1100delC; c.444+1G>A; del5395; p.I157T |
1.0 (0.4–2.6); 1.0—truncations 1.7 (1.2–2.4); 0.007—p.I157T |
| Kleibl 2009 [235] |
CZ | P: 631 CRC C: 683 PMC |
FHA-coding region c.1100delC;5395del |
2.3 (1.3–4.0); 0.003—all variants in FHA domain 2.0 (1.1–3.6); 0.03—p.I157T only 2.3 (0.4–12.8); 0.4—c.1100delC; zero 5395del carriers |
| Weischer 2007 [162] |
DK | P: 210 (prospective) C: 9007 PMC (prospect.) |
c.1100delC | 1.6 (0.4–6.5)—prospective CRC |
| Cybulski 2007 [236] |
PL | P. 1085 unselected CRC C: 5496 controls |
c.1100delC; c.444+1G>A; del5395; p.I157T |
1.0 (0.5–1.8); 0.9—truncations 1.5 (1.2–2.0); 0.002—p.I157T |
| Djureinovic 2006 [237] |
SE | P: 174 familial CRC P: 644 unselected CRC C: 760 PMC |
c.1100delC |
1.76 (0.34–9.09); 0.6—familial CRC 1.42 (0.43–4.67); 0.7—sporadic CRC |
| Irmejs 2006 [133] |
LV | P: 235 C: 978 newborn PMC |
p.I157T | 1.7 (1.01–2.70); p < 0.05 |
| Meijers-Heijboer 2003 [228] |
UK/NL/ US/CA |
P: 329 CRC C: 1620 [167] |
c.1100delC (ASO) |
2.34 (0.95–5.79); 0.07—HNPCC-like families 5.19 (2.17–12.4); < 0.001—HBCC families |
CZ—Czech Republic; DK—Denmark; LV—Latvia; NL—the Netherlands; PL—Poland; SE—Sweden; UK—the United Kingdom, US—the USA. The analyses that failed to demonstrate an association are shown in italics.