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Gene set enrichment analysis (GSEA) of the GSE41485 dataset (a). SCD1 has a role in RCC resistance to cisplatin (CDDP)-induced cytotoxicity (C). The death rate of treated tumor cells (tumor + A939572 + CDDP) is significantly higher than that of untreated cells (tumor + CDDP) (p < 0.001). No difference is observed in normal cells (p > 0.05) (b). MTT assay reveals significantly decreased cell viability when RCC cells are treated with A939572 before cisplatin incubation (c).
