Table 2.

The variants of RBM at five critical positions in SARS-CoV (442, 472, 479, 480 and 487).

Virus	Position 1	Position 2	Position 3	Position 4	Position 5
SARS-CoV	F > Y, Y, S	F > L > P, L = P, F	N, R > K = N, N	D > G, G > D, D	T >> S, S, N
SARS-CoV-2	L	F	Q	S	N

Red color is for human, cyan for civet and violet for bat. The corresponding positions in SARS-CoV-2 for human are Leu455, Phe486, Qln493, Ser494 and Asn501. The effects on affinity with ACE2 of different mutations at any position for any reservoir are indicated by symbols like “>” (greater than), “>>” (much greater than), and “=” (equal to).