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. 2020 Dec 8;21(24):9362. doi: 10.3390/ijms21249362

Figure 2.

Figure 2

Proteomic analysis of hepatic proteins differentially expressed (DE) by both risperidone and olanzapine. (A) Venn diagrams showing shared proteins that are significantly upregulated (top) or downregulated (bottom) in risperidone (RIS)- or olanzapine (OLAN)-treated mice (p < 0.05). (B) Of the 20 shared proteins, 9 were found to have KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway maps from which predicted functional changes could be determined. Statistical significance (p < 0.5) of differentially expressed (DE) proteins relative to vehicle (VEH). RIS n = 5; OLAN n = 4; VEH n = 4. Abbreviations: NAFLD, non-alcoholic fatty liver disease; GI, gastrointestinal.