Table 3.
Significantly overrepresented proteins differentially expressed in livers from animals treated with risperidone or olanzapine.
| Risperidone | |||||
| Upregulated | Name | # KEGG Pathways | Downregulated | Name | # KEGG Pathways |
| PRKCA | Protein kinase C alpha | 53 | ALDH7A1 | Aldehyde dehydrogenase 7, member a1 | 14 |
| GNAS | Guanine nucleotide-binding protein, alpha-stimulating | 40 | COX6B1 | Cytochrome C oxidase subunit 6B1 | 11 |
| PDGFRB | Platelet-derived growth factor receptor beta | 18 | AOX3 | Aldehyde oxidase 3 | 9 |
| ROCK2 | Rho-associated coiled-coil-containing protein kinase 2 | 15 | ENO3 | Enolase 3 | 8 |
| ITGA3 | Integrin alpha 3 | 11 | AGXT | Alanine-glyoxylate and serine-pyruvate aminotransferase | 7 |
| GSTA3 | Glutathione-S-transferase A3 | 10 | CS | Citrate synthase oxidoreductase core subunit S1 | 7 |
| NDUFA8/ NDUFB8 | Inner mitochondrial membrane complex 1 NADH:ubiquinone oxidoreductase subunit A8/B8 | 7/7 | NDUFS1 | NADH ubiquinone | 7 |
| PGAM2 | Phosphoglycerate mutase 2 | 7 | ABAT | 4-Aminobutyrate aminotransferase | 7 |
| BCAT2 | Branched-chain amino acid transaminase 2 | 7 | ALR1 | Aldo-keto reductase family 1 member B | 6 |
| AFDN | Afadin | 6 | |||
| INPP5D | Inositol polyphosphate 5-phosphatase D | 6 | |||
| ACAA2 | Acetyl CoA acyltransferase 2 | 6 | |||
| ADIPOQ | Adiponectin, C1Q, and collagen domain-containing | 6 | |||
| DGKZ | Diacylglycerol kinase-zeta | 6 | |||
| EPHA2 | EPH-ephrin receptor A2 | 5 | |||
| Olanzapine | |||||
| Upregulated | Name | # KEGG Pathways | Downregulated | Name | # KEGG Pathways |
| GLB1 | Beta-galactosidase | 12 | GNAI1 | G-protein subunit alpha inhibitory-1 | 37 |
| G6PD | Glucose 6 phosphate dehydrogenase | 10 | CYCS | Somatic cytochrome C | 26 |
| ATP2B4 | ATPase plasma membrane Ca+2 transporting 1 | 9 | COX6B1 | Cytochrome C oxidase subunit 6B1 | 11 |
| INPP5D | Inositol polyphosphate 5-phosphatase D | 6 | ENO3 | Enolase 3 | 8 |
| AGPAT3 | 1-Acylglycerol-3-phosphate O-acyltransferase-3 | 5 | ACE | Angiotensin I-converting enzyme | 7 |
| CFL1 | Cofilin 1 | 5 | PNP | Purine nucleoside phosphorylase | 6 |
| AK2 | Adenylate kinase 2 | 5 | |||
| ATIC | 5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 5 | |||
| AMY2B | Amylase alpha 2B | 5 | |||
KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis of risperidone- and olanzapine-associated changes in liver protein expression compared to VEH controls. #—indicates “number”. “Up” and “Down” respectively indicate increased or decreased instances of each function on KEGG pathways as a result of changes in the associated protein expression (see Supplementary File S3 for detailed correlations). RIS n = 5; OLAN n = 4; VEH n = 4. Abbreviations: RIS, risperidone; OLAN, olanzapine; OxPhos, oxidative phosphorylation; TCA, tricarboxylic acid cycle; ETC, electron transport chain; GI, gastrointestinal; ROS, reactive oxygen species.