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. 2020 Nov 10;9(22):e017751. doi: 10.1161/JAHA.120.017751

Figure 5. The Akt/GSK3β/mTOR/p70‐S6K signaling pathways are involved in USP10‐regulated cardiac hypertrophy.

Figure 5

A and B, The phosphorylation and total protein levels of Akt, GSK3β, mTOR, and p70‐S6K in heart tissues from USP10‐Flox and USP10‐CKO mice (A) or NTG and USP10‐TG mice (B) at 4 weeks after AB surgery. C and D, The protein levels of phosphorylated and total Akt, GSK3β, mTOR, and p70‐S6K in NRCMs infected with AdshRNA and AdshUSP10 (C) or AdGFP and AdUSP10 (D) treated with Ang II (angiotensin II). AB indicates aortic banding; Akt, protein kinase B; CKO, cardiac‐specific knockout; GAPDH, glyceraldehyde‐3‐phosphate dehydrogenase; GSK3β, glycogen synthase kinase‐3 beta; mTOR, mammalian target of rapamycin; NTG, nontransgenic; p70‐S6K, endogenous 70‐kDa S6 kinase; TG, transgenic; and USP10, ubiquitin‐specific protease 10.