Table 3.
Characteristics of Patients From the Clinical Laboratory Database
| Variables | Categories of "LDL‐C," mg/dL | ||||||
|---|---|---|---|---|---|---|---|
| <70 (n = 83 807) | 70‐<100 (n = 178 245) | 100‐<130 (n = 157 576) | 130‐<190 (n = 103 597) | ≥190 (n = 7,919) | t Statistic for Trend* | P Value for trend* | |
| Age, y | 61 (15) | 57 (15) | 54 (14) | 54 (13) | 55 (13) | −114 | <0.0001 |
| Female sex, n (%) | 36 759 (44) | 92 035 (52) | 84 860 (54) | 57 118 (55) | 4830 (61) | 50† | <0.0001† |
| Total cholesterol, mg/dL | 136 (31) | 166 (23) | 196 (23) | 235 (28) | 304 (42) | 968 | <0.0001 |
| HDL‐C, mg/dL | 50 (17) | 53 (16) | 55 (15) | 55 (14) | 59 (14) | 78 | <0.0001 |
| Triglycerides, mg/dL | 92 (66–136) | 101 (72–146) | 111 (80–158) | 130 (95–179) | 155 (115–213) | 141 | <0.0001 |
| ApoB, mg/dL | 60 (12) | 79 (12) | 99 (13) | 124 (17) | 166 (25) | 1188 | <0.0001 |
| LDL particles, nmol/L | 924 (293) | 1299 (316) | 1652 (361) | 2099 (449) | 2808 (486) | 820 | <0.0001 |
| Lipoprotein(a) mass, mg/dL | 14 (6–36) | 16 (7–46) | 17 (8–48) | 20 (8–56) | 25 (10–72) | 64 | <0.0001 |
| Lp(a)‐C30, mg/dL | 4 (2–11) | 5 (2–14) | 5 (2–14) | 6 (2–17) | 8 (3–22) | 64 | <0.0001 |
| “LDL‐C,” mg/dL | 57 (10) | 85 (9) | 113 (9) | 149 (15) | 211 (26) | NA | NA |
| LDL‐Ccorr30, mg/dL | 49 (13) | 75 (14) | 103 (15) | 138 (19) | 197 (29) | 1399 | <0.0001 |
Data shown are means (SDs), medians (interquartile ranges), or counts (percentages). Lp(a)‐C30 was estimated as 30% of lipoprotein(a) mass. LDL‐Ccorr30 was estimated by subtracting Lp(a)‐C30 from “LDL‐C”. Of 531 144 people, 15 had a missing value of age, triglycerides, total cholesterol, or HDL‐C, which was mean imputed for this analysis. Descriptive summaries of corrected LDL‐C values assuming other proportions of lipoprotein(a) cholesterol content are provided in Table S4. ApoB indicates apolipoprotein B; HDL‐C, high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; and NA, not available.
t Statistics and P values for trend were calculated using linear regression, unless specified otherwise.
Numbers are z statistics and P values for trend, calculated using logistic regression.