Table 1.
Summary of Studies Investigating AERP in Nonremodeled Atria
| Year of Publication, First Author | Subjects, N | Incremental or Decremental | Stimulus Strength | Location | BCL (ms) | AERP (ms) | Comment |
|---|---|---|---|---|---|---|---|
| Experimental studies | |||||||
| 1995, Wijffels 7 | Goats, 12 | Incremental, 2‐ms steps | 4× threshold | RA, LA | Max | 117±12 | Small study population |
| 200 | 131±11 | ||||||
| 250 | 145±13 | ||||||
| 1995, Morillo 24 | Dogs, 10 | Decremental, 10‐ms steps | 2×DT | RA | 300 | 147±11 | Small study population |
| 400 | 150±8 | ||||||
| 1995, Wijffels 7 | Goats, 12 | Incremental, 2‐ms steps | 4× threshold | RA, LA | 400 | 146±19 | Small study population |
| Clinical studies | |||||||
| 2001, Brundel 23 | 13 | … | … | LAA, RAA | 250 | 184±5 | Small study population, anesthesia |
| 300 | 224±16 | ||||||
| 1996, Daoud 6 | 20 | Incremental, 5‐ms steps | 3× threshold, mean 0.7±0.2 mA | RA (2 sites) | 350 | 206±23 | |
| 1995, Capucci 21 | 10 | Decremental, 1‐ms steps | 2.5×DT | RA, CS, or LA | 400 | 266±37 | Small study population |
| 2001, Brundel 23 | 13 | … | … | LAA, RAA | 400 | 252±34 | Anesthesia |
| 1987, Soni 2 | 11 | Decremental, steps: ‐ | 3 mA | RA | 436±81 | 225±29 | BCL not standardized |
| 1995, Capucci 21 | 10 | Decremental, 1‐ms steps | 2.5×DT | RA, CS, or LA | 500 | 267±42 | Small study population |
| 1996, Daoud 6 | 20 | Incremental, 5‐ms steps | 3× threshold, mean 0.7±0.2 mA | RA (2 sites) | 500 | 216±17 | |
| 2001, Brundel 23 | 13 | … | … | LAA, RAA | 500 | 277±42 | Anesthetics, sternotomy |
| 2010, Centurion 25 | 62 | Decremental, 10‐ms steps | 2×DT | RA, CS | 500 | 215±29 | |
| 1995, Capucci 21 | 10 | Decremental, 1‐ms steps | 2.5×DT | RA, CS or LA | 600 | 281±35 | Small study population |
| 1998, Chen 27 | 20 | Incremental, 10‐ms steps | 2×DT | RA | 600 | 211±26 | |
| 2001, Brundel 23 | 13 | … | … | LAA, RAA | 600 | 291±53 | Anesthetics |
| 2002, Kim 10 | 9 | … | … | RA (6 sites) | 600 | 227±20 | Small study population |
| 2016, Lee 28 | 1308 | Decremental, 10‐ms steps | 2× threshold | RA | 600 (in 93%) | 233±31 | BCL not standardized |
| 1985, Alboni 26 | 20 | Decremental, 10‐ms steps | 2×DT | RA | 680±68 | 211±27 | BCL not standardized |
| 1987, Soni 2 | 11 | Decremental, steps: ‐ | 3 mA | RA | 709±80 | 250±38 | BCL not standardized |
“‐” indicates no details provided; AERP, atrial effective refractory period; BCL, basic drive cycle length; CS, coronary sinus; DT, diastolic threshold; LA, left atrium; LAA, left atrial appendage; RA, right atrium; and RAA, right atrial appendage.