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. 2020 Dec 9;21(24):9367. doi: 10.3390/ijms21249367

Figure 1.

Figure 1

Upregulated mRNA expression for PDK1 and PDK3 correlates to hypoxia-related gene signatures in triple-negative and basal-like breast cancers. (a) PDK1–4 mRNA expression (RNA-seq) in non-triple-negative breast cancer (non-TNBC) subtype vs. TNBC cases. (b) PDK1–4 mRNA expression (RNA-seq) in different breast cancer subtypes classified by the Pam50 classification of the TCGA dataset (luminal A, luminal B, HER2+ and Basal). (c) Number of samples in TCGA dataset that have a z-score of z > 2 for PDK1–4 in different breast cancer subtypes classified by the Pam50 classification system. (d) The Buffa hypoxia score (left) and the Ragnum hypoxia score (right) correlates with the overexpression (z >2) of PDK1–4 mRNA. **** p < 0.0001.