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Various invasive technologies to increase drug delivery to the brain by bypassing the BBB/NVU include intrathecal injection via a lumbar puncture and various intracranial techniques. These include (A) intracerebroventricular injection using the Ommaya reservoir, (B) convection-enhanced delivery (CED) by way of intracerebral catheter placement, and (C) placement of drug-loaded polymeric wafers.
