Table 1.

Host kinases and their roles in chlamydial infection.

Host Kinase	Implicated Roles in Chlamydial Infection	References
Src, Abl, Syk	Phosphorylation T3SS effectors TarP and TepP. Important for entry, inclusion development and regulation of innate immune response	[17,18,19,20,21,22]
FAK	Recruited by TarP Actin remodeling during entry	[23,24]
SFKs (Src, Fyn)	Microdomain localization Microtubule dependent trafficking of inclusion to MTOC Intracellular development Lipid acquisition	[25,26,27]
MLCK	Microdomain localization with other elements of Myosin pathway Regulation of extrusion	[28,29,30]
RTKs (PDGFR, FGFR, EGFR, EPHA2)	Chlamydial entry and invasion F-actin assembly around inclusion Host cell survival	[18,31,32,33,34]
PI4KIIα	Generation of a pool of PI4P around inclusion Important for infectious progeny and inclusion formation	[35]
PI3K/AKT	Invasion Apoptosis resistance Chlamydial replication Dampening of innate immune response Sphingolipid acquisition Reduction of tumor suppressor protein p53	[21,34,36,37,38,39,40,41]
PDPK1	Apoptosis resistance	[42]
GSK3β	Interacts with Cpn1027 Recruitment by TepP	[21,43]
PKC	Resistance to apoptosis Microdomain localization Potential role in lipid acquisition	[44,45,46,47]
MEK/ERK	Lipid acquisition Bacterial replication Apoptosis resistance cytokine IL-8, IL-10 induction Chlamydia induced epithelial-to-mesenchymal transition Proliferation of vasculature smooth muscle cells	[18,23,31,32,36,40,48,49,50,51,52,53,54,55,56,57,58]