Figure 2.

Inverse correlation between the extent of GLUT-1^high expression on tumor cells and cytotoxic T-lymphocytes (CTL) infiltration. On the level of the entire whole-slide images, the amount of GLUT-1^high tumor cells and the strength of the tumor infiltration by CD8+ CTL show a significant negative correlation (Spearman’s r: −0,39, p = 0.0252). This highlights the observation of systematic avoidance of presumably hypoxic, GLUT-1^high tumor cell areas by CTL. The tumor samples included in this analysis were derived from the following tissues: Brain (2), Skin of the Ear (1), Gastrointestinal tract (1), Lymph node (13), Lung (2), Myocardium (1), Mucosa of the palate (1), Rectum (1), and Skin (11). Statistical analysis was performed using a two-sided Spearman’s correlation analysis.