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. 2020 Dec 11;25(24):5847. doi: 10.3390/molecules25245847

Scheme 1.

Scheme 1

Synthesis of garcinoic acid and its analogs. Reagents and conditions: (a) imidazole, TBSCl, CH2Cl2, rt; (b) Grubbs catalyst, 2nd generation, toluene, reflux; (c) (i) LiOH, THF:MeOH:H2O, 45 °C, overnight; (ii) 1N HCl; (d) TBAF, THF, 0 °C–rt.