Table 1.

Screening of reaction conditions for cross metathesis between 4 and 5.

Entry	Catalyst a	Substrate	Solvent	Temp	Time	Yield % (6/7/8) b
1	Grubbs 1st generation	5b	CH2Cl2	rt	24 h	0
2	Grubbs 1st generation	5b	CH2Cl2	reflux	24 h	0
3	Grubbs 1st generation	5b	1,2-DCE	reflux	24 h	0
4	Grubbs 1st generation	5b	toluene	reflux	24 h	0
5	Grubbs 2nd generation	5b	CH2Cl2	reflux	24 h	Trace
6	Grubbs 2nd generation	5b	toluene	reflux	3 h	54/14/8
7	Grubbs 2nd generation	5b	toluene	reflux	24 h	62/15/trace
8	Grubbs 2nd generation	5b	neat	80 °C	24 h	Trace
9	Grubbs 2nd generation	5a	CH2Cl2	rt	24 h	0
10	Grubbs 2nd generation	5a	CH2Cl2	reflux	24 h	0
11	Grubbs 2nd generation	5a	1,2-DCE	reflux	24 h	Trace
12	Grubbs 2nd generation	5a	toluene	reflux	24 h	17/15/11

^a5 mol % of the catalyst was used; ^bIsolated yield of products 6, 7, and 8.