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. 2020 Dec 10;21(24):9391. doi: 10.3390/ijms21249391

Figure 2.

Figure 2

(A): Effects induced by allotetrahydrodeoxycorticosterone (THDOC) on the 4AP-induced epileptiform activity generated in vitro by the piriform cortex obtained from non-epileptic control (NEC) rodents. Note that both interictal (enlarged sample) and ictal discharges can be recorded during application of 4AP and following the addition of THDOC. (B): 4AP-induced interictal and ictal discharges recorded from the piriform cortex of brain slices obtained from epileptic (Pilocarpine-treated) rodents in 4AP and following bath application of THDOC. (C): Quantification of the interictal events and ictal events recorded from the piriform cortex during 4AP application and after application of THDOC in brain slices obtained from NEC and pilocarpine-treated animals. (D): Quantification of the interictal and ictal events recorded from the entorhinal cortex during 4AP application and after application of THDOC in brain slices obtained from NEC and pilocarpine-treated animals. * indicates p < 0.05; ** indicates p < 0.01. Panels shown in this figure are modified from the study by Shiri et al. [17].