Table 4.
Diagnostic test accuracy measurements for salivary metabolites breast cancer.
| Metabolites | AUC | CI 95% | Optimal Cutoff Value | Sensitivity | CI 95% | Specificity | CI 95% |
|---|---|---|---|---|---|---|---|
| PG14:2 | 0.7329 | 0.5962–0.8697 | 19,325.80 | 65.22% | 42.77–83.62% | 77.14% | 59.86–89.58% |
| PA 32:1 | 0.5988 | 0.4319–0.7656 | 1915.30 | 60.87% | 38.54–80.29% | 60.00% | 42.11–76.23% |
| PS 28:0 | 0.6273 | 0.4644–0.7902 | 25,012.90 | 47.83% | 26.82–69.41% | 88.57% | 73.26–96.80% |
| PI 31:1 | 0.5876 | 0.4250–0.7502 | 37,403.88 | 43.48% | 23.19–65.51% | 82.86% | 66.35–93.44% |
| PS 40:6 | 0.5950 | 0.4357–0.7544 | 12,784.24 | 56.52% | 34.49–76.81% | 57.14% | 39.35–73.68% |
| PI 38:7 | 0.6609 | 0.5132–0.8085 | 1951.16 | 60.87% | 38.54–80.29% | 71.43% | 53.70–85.36% |
| H-His-Lys-(Ala-Ser)-OH or (Gly-Thr)-OH |
0.7280 | 0.5962–0.8597 | 6274.70 | 73.91% | 55.97–91.86% | 62.86% | 46.85–78.86% |
| H-Phe-Phe-Gln-Trp-OH | 0.7478 | 0.6113–0.8844 | 1961.38 | 73.91% | 55.97–91.86% | 74.29% | 59.81–88.77% |
| H-Phe-Ile-Gln-Arg-OH | 0.6795 | 0.5373–0.8218 | 2406.38 | 69.57% | 50.76–88.37% | 68.57% | 53.19–83.95% |
| H-Arg-Arg-Ser-OH | 0.6621 | 0.5137–0.8105 | 4842.48 | 73.91% | 55.97–91.86% | 51.43% | 34.87–67.99% |
| H-Glu-Phe-Gln-Arg-OH or H-Ile-Lys-Gln-Trp-OH |
0.6565 | 0.4961–0.8170 | 5926.30 | 60.87% | 40.92–80.81% | 80.00% | 66.75–93.25% |
| H-Phe-Lys-Lys-Trp-OH or H-Phe-Gln-Arg-Tyr-OH |
0.6783 | 0.5356–0.8209 | 6499.44 | 56.52% | 36.26–76.78% | 74.29% | 59.81–88.77% |
| H-Ala-Lys-Phe-Trp_OH or H-Gly-Lys-Thr-Ser-OH or H-Arg-Arg-Ser-Ser-OH | 0.6497 | 0.5028–0.7966 | 3266.77 | 60.87% | 40.92–80.81% | 62.86% | 46.85–78.86% |
| m/z 602.96 | 0.6584 | 0.5005–0.8163 | 6006.47 | 56.52% | 36.26–76.78% | 71.43% | 56.46–86.39% |
| m/z 749.4 | 0.6696 | 0.5186–0.8205 | 3542.90 | 65.22% | 45.75–84.68% | 65.71% | 49.99–81.44% |
| m/z 456.72 | 0.7441 | 0.6080–0.8802 | 101,578.83 | 69.57% | 50.76–88.37% | 74.29% | 59.81–88.77% |
| m/z 475.70 | 0.7391 | 0.5979–0.8803 | 7027.85 | 65.22% | 45.75–84.68% | 74.29% | 59.81–8877% |
| m/z 467.71 | 0.7702 | 0.6473–0.8931 | 8138.34 | 73.91% | 55.97–91.86% | 65.71% | 49.99–81.44% |
| m/z 614.32 | 0.6665 | 0.5135–0.8194 | 11,030.99 | 52.17% | 31.76–72.59% | 77.14% | 63.23–91.05% |
| m/z 457.73 | 0.6497 | 0.5132–0.8085 | 11,204.51 | 60.87% | 40.92–80.81% | 60.00% | 43.77–76.23% |
| m/z 356.69 | 0.6845 | 0.5384–0.8306 | 2956.67 | 47.83% | 27.41–68.24% | 82.86% | 70.37–95.34% |
| m/z 467.71 | 0.6857 | 0.5452–0.8262 | 12,496.76 | 73.91% | 55.97–91.86% | 60.00% | 43.77–76.23% |
| m/z 534.23 | 0.6826 | 0.5389–0.8263 | 3642.90 | 65.22% | 45.75–84.68% | 65.71% | 49.99–81.44% |
| m/z 1015.04 | 0.6609 | 0.5103–0.8114 | 9239.95 | 65.22% | 45.75–84.68% | 68.57% | 53.19–83.95% |
| m/z 413.22 | 0.6783 | 0.5365–0.8200 | 2335.12 | 73.91% | 55.97–91.86% | 57.14% | 40.75–73.54% |
| m/z 602.32 | 0.6646 | 0.5182–0.8110 | 4543.59 | 60.87% | 40.92–80.81% | 65.71% | 49.99–81.44% |
| m/z 661.34 | 0.7025 | 0.5670–0.8380 | 1690.58 | 69.57% | 50.76–88.37% | 65.71% | 49.99–81.44% |
| m/z 875.49 | 0.5652 | 0.4024–0.7281 | 14,840.39 | 39.13% | 19.19–59.08% | 77.14% | 63.23–91.05% |
| m/z 594.82 | 0.6857 | 0.4024–0.7281 | 619.06 | 86.96% | 73.19–100.00% | 51.43% | 34.87–67.99% |
| m/z 614.82 | 0.8124 | 0.4024–0.7281 | 2749.30 | 82.61% | 67.12–98.10% | 77.14% | 63.23–91.05% |
| m/z 818.47 | 0.6186 | 0.4622–0.7751 | 7969.76 | 60.87% | 40.92–80.81% | 62.86% | 46.85–78.86% |
AUC: area under curve, CI: confidence interval; m/z = mass-to-charge ratio; ROC: Receiver operating characteristic.