Table 2.
Examples of studies demonstrating the clinical relevance of circulating tumor cells and ctDNA.
| Early Breast Cancer/Advanced Disease | Liquid Biopsy | Method | Prognostic/Predictive Value or Monitoring | References |
|---|---|---|---|---|
| Early breast cancer | CTCs | CellSearch® | Prognostic | [42,44,45,46] |
| Advanced disease | CTCs | CellSearch® | Prognostic | [43] |
| Advanced disease | CTCs | CellSearch® | Prediction | [47,50] |
| Early breast cancer | CTCs | CellSearch® | Prediction | [48,51] |
| Advance disease | ctDNA | ddPCR | Prediction and monitoring | [53] |
| Early breast cancer | ctDNA | ddPCR | Prognostic | [54] |
| Advanced disease | ctDNA | ddPCR | Prediction and prognostic | [55] |
| Advanced disease | ctDNA | Signatera™ | Prognostic | [56] |
| Early breast cancer and Locally advanced disease | ctDNA | TARDIS | Prediction and monitoring | [57] |