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. 2020 Dec 11;10(12):2377. doi: 10.3390/ani10122377

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 3 — Graphic representation of the main respiratory lesions associated with Coronavirus infections in animals. Affected upper (top box) and lower (bottom box) respiratory tract: the healthy tissue is represented on the left side of the boxes and the lesions on the right side. The species mainly affected by respiratory lesions are represented on the lower left corner. Lesions of the upper airways are mainly characterized by mucosal inflammation consisting of neutrophilic (or heterophilic) and lymphocytic infiltrate, sloughing of epithelial cells, loss of cilia, epithelial cell hyperplasia, and hypertrophy of mucosal glands. Lesions in the lungs are mainly characterized by hemorrhages with neutrophilic (or heterophilic) and lymphocytic infiltrate, severe edema, epithelial cell detachment, and fibrinous exudate. The scheme has been created with BioRender.com.