Figure 8.

Amino acid sequence alignment for the S100 proteins specific to IFN-β, derived from overlay of their tertiary structures on that for human S100P using DALI server [59]. The residues of the primary monomers of the S100 proteins involved in the interaction with either target proteins (panel A) or human IFN-β (B), determined with LPC software [60], are shown in bold. Model structures of the S100—IFN-β complexes are shown in Figure 8. The residues of the secondary monomers of the S100 proteins predicted to be involved in the interaction with IFN-β are underlined (B). PDB codes used for the analysis and secondary structure elements (“L” and “H” denote loops and α-helices, respectively) are indicated.